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. 2000 Oct;131(3):505–513. doi: 10.1038/sj.bjp.0703586

Figure 4.

Figure 4

Effects of caffeine on the 10 mM UDP-induced current in a conventional whole-cell configuration at −50 mV. UDP (10 mM) was included in the pipette solution. Bath solution 140 mM K+ PSS, pipette solution 140 mM K+ containing 5 mM EGTA. The dashed lines indicate the zero current level. (a) When a small inward current developed slowly after the established of the conventional whole-cell configuration (indicated by the filled arrow), caffeine (10 mM) reversibly inhibited the 10 mM UDP-induced inward current. Subsequently, application of 5 μM glibenclamide suppressed the UDP-induced inward current. (b) When the amplitude of the UDP-induced current became stable at −50 mV, application of 300 μM caffeine caused no effect on the UDP-induced membrane current.