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. 2000 Oct;131(3):645–650. doi: 10.1038/sj.bjp.0703599

Figure 2.

Figure 2

Inhibition [3H]-ACh release in hippocampal synaptosomes by WIN 55212. Synaptosomes were perfused with WIN 55212-2 either alone or in the presence of 300 nM 141716A. [3H]-ACh release was evoked by (a) 1.3 mM calcium or (b) 11 mM potassium. Data are means (±s.e.mean) of 8–10 determinations and are shown as a percentage of their respective controls (either vehicle or 300 nM SR 141716A, alone). ANOVA: 1.3 mM calcium with no SR 141716A, F(4,44)=16.8, P<0.01; 11 mM potassium with no SR 141716A, F(4,32)=4.1, P<0.01; 1.3 mM calcium+SR141716A, F(4,33)=6.9, P<0.01; 11 mM potassium+SR141716A, F(4,33)=9.8, P<0.01. *P<0.05, **P<0.01 versus control (Dunnett's test). Control values (fractional release): 1.3 mM calcium with no SR 1414716A, 0.0153±0.0012; 11 mM potasssium with no SR 14176A, 0.0215±0.0017; 1.3 mM calcium+SR 141716A, 0.0158±0.0017; 11 mM potassium+SR 141716A, 0.0167±0.0009.