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Effects of MT-7 on CCh-stimulated [3H]-IPs accumulation (A) and CCh-induced inhibition of PACAP38-stimulated cyclic AMP accumulation (B) in N1E-115 neuroblastoma cells. Cells were pretreated with the indicated concentrations of MT-7 for 30 min at 37°C and then exposed to the indicated concentrations of CCh. In (B), PACAP 38 was also added at the final concentrations of 10 nM. Data are the mean±s.e.mean of three experiments for both assays.
