Effect of guanethidine (guan), guanethidine+L-NNA, guanethidine+the non-selective VIP receptor antagonist (VIPra) and guanethidine+L-NNA+the non-selective VIP receptor antagonist on the mean relaxation induced by manipulation of the small intestine and caecum resection. Results are expressed as per cent of the SNP-induced relaxation and are shown as mean±s.e.mean for n=3–7 animals. *P<0.05, different from control, Student's t-test; #P<0.05, different from guanethidine, Student's t-test.