Figure 1.

Inhibitory effect of high molecular weight ATA on thrombus formation in the carotid artery of tPA−/−, uPA−/−, PAI-1−/− or wild type mice. The carotid arterial blood flow was continuously monitored for 60 min after the initiation of endothelial injury using a photochemical reaction. Time to occlusion is given as mean±s.e.mean in each experiment. Times greater than 60 min are given as 60 min for calculation of mean±s.e.mean ^*P<0.05, ^**P<0.01 versus each control (infusion of saline). #P<0.05 versus PAI-1+/+ mice.