Figure 4.

Concentration-response curves of bradykinin- and substance P-induced EDHF relaxations in the presence of 100 μM nitro-L-arginine and 10 μM indomethacin. The relaxations caused by the peptides are expressed in % of the tonic contraction produced throughout the experiment by 0.3 μM U 46619. Effect of 2 μM BaCl2, an inhibitor of inward rectified potassium channels (A and D); of 40 μM 18α glycyrrethinic acid (B and E) and of 50 μM palmitoleic acid, two inhibitors of cell to cell communication through gap junctions (C and F).