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Concentration-response curves of bradykinin- and substance P-induced EDHF relaxations in the presence of 10 μM indomethacin and 100 μM nitro-L-arginine. The relaxations caused by the peptides are expressed in % of the tonic contraction produced throughout the experiment by 0.3 μM U 46619. Effect of 500 nM ouabain. The effect of ouabain is also shown in experiments done without indomethacin and nitro-L-arginine to show the role of nitric oxide.
