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. 2000 Nov;131(6):1081–1088. doi: 10.1038/sj.bjp.0703654

Figure 5.

Figure 5

Effect of mizolastine on IHERG1 constitutively expressed in SH-SY5Y human neuroblastoma cells. Representative current traces recorded in the whole-cell configuration of the patch-clamp technique from an SH-SY5Y human neuroblastoma cell recorded in control conditions and after subsequent perfusion with 100 nM and 1 μM mizolastine (5 min each). The pulse protocol (shown at the bottom of the Figure) was the following: holding potential: −70 mV; depolarizing test potential: 0 mV for 10 s; hyperpolarizing return potentials: from 0 to −120 mV in −20 mV steps for 365 ms; return potential: −70 mV. Only approximately the last 450 ms of each pulses are shown, as indicated by the boxed area in the voltage pulse protocol.