Figure 1.

Effect of Cloricromene on the onset, the secondary lesion and on body weight gain in collagen-induced arthritis. The percentage of arthritic rats (rats showing clinical scores of arthritis>1) are represented (A). There was a significant increase in the arthritic score from day 26 (P<0.01) (B). Beginning on day 25, the collagen-challenged rats gained significantly less weight than the normal rats, and this trend continued through day 35 (C). The swelling in hind paws (D) over time (ml) was measured at 2-day intervals. Cloricromene was able to positively affect in a dose-dependent manner the percentage of arthritic rats, the arthritic score, the weight gain as well as the paw oedema of CII-immunized rats. Values are means±s.e.mean of 10 animals for each group. ^*P<0.01 versus Control °P<0.01 versus CIA.