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Concentration-response curves showing the relaxations induced by (a) acetylcholine (ACh) and (b) sodium nitroprusside (SNP) in aorta from control mice and mice deficient of apolipoprotein E and low density lipoprotein receptor genes (E°xLDLR°). The relaxations are expressed in per cent of the precontracted tone induced by 10 μM phenylephrine. Data are given as means and s.e.mean of 10–12 observations. Significant differences between the groups are shown; ***P<0.001.
