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Concentration-response curves showing the relaxations induced by sodium nitroprusside (SNP) in aorta from mice deficient of apolipoprotein E and low density lipoprotein receptor genes (E°xLDLR°) under control conditions and after preincubation with the combination of L-arginine and tetrahydrobiopterin (BH4). The relaxations are expressed in per cent of the precontracted tone induced by 10 μM phenylephrine. Data are given as means and s.e.mean of seven observations.
