Figure 5.

Concentration-response curves showing the relaxations induced by acetylcholine (ACh) in aorta from mice deficient of apolipoprotein E and low density lipoprotein receptor genes (E°xLDLR°) under control conditions and after preincubation with (a) superoxide dismutase (SOD) and (b) the combination of L-arginine and tetrahydrobiopterin (BH₄), and L-arginine+BH₄+SOD. The relaxations are expressed in per cent of the precontracted tone induced by 10 μM phenylephrine. Data are given as means and s.e.mean of six observations. Significant differences from control conditions are shown; ^*P<0.05, ^**P<0.01.