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Concentration-response curves showing the contractions induced by endothelin-1 (ET-1) in aorta from control mice and mice deficient of apolipoprotein E and low density lipoprotein receptor genes (E°xLDLR°). The contractions are expressed in per cent of that evoked by 60 mM potassium. Data are given as means and s.e.mean of 11–14 observations. Significant differences between the groups are shown; ***P<0.001.
