Figure 3.

The contractile effects of thrombin receptor activating peptide on the rat myometrium. (a) and (b) Representative traces showing the effects of PAR1-AP (10 μM) on the tension of the non-pregnant rat myometrium (a) and on the [Ca²⁺]_i (upper trace) and tension (lower trace) of the pregnant rat myometrium (b) in the normal PSS. (c) The concentration-response curves of PAR1-AP-induced contraction. The tension development was evaluated by the area under the tension trace for the initial 10 min, assigning the values obtained with 40 mM K⁺ PSS to be 100%. The data are the mean±s.e.mean (n=5–7).