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Run-down of P2X receptor currents in the whole cell recording mode. (A) α,β-meATP (10 μM) evokes transient inward currents which desensitize rapidly during agonist application (200 ms, application indicated by bar). The peak amplitude of currents ‘ran-down' during repeated applications of α,β-meATP at 5 min intervals. (B) The timecourse of run-down of P2X currents in the whole cell recording mode. Recovery from desensitization is maximal with a 3–5 min interval between applications.
