Figure 7.

Antagonism of P2X receptor-mediated currents in rat mesenteric artery smooth muscle cells. (A) The response to α,β-meATP (3 μM) is abolished by 30 μM suramin, note the potentiation of the response on washout. (B) iso-PPADS (1 μM) abolished the response to α,β-meATP (3 μM), this effect was partially reversed after 5 mins washout. (C) Summary of the concentration dependence of inhibition of α,β-meATP (3 μM) evoked responses by the antagonists suramin and iso-PPADS. (n=4–6 for each point).