Figure 4.

Histopathologic changes of left tibiotalar joints of non-adjuvant control (A), adjuvant control (B), BAY 12-9566-treated (C), and Indomethacin-treated (D) rats. Destructive inflammation was remarkable in the tibiotalar joints of the adjuvant controls (B). This section shows marked inflammatory infiltrate in both synovial and bone tissues, destruction of bone trabeculae, thinning of the articular plate and new bone formation. The inflammation was suppressed in the joints of BAY 12-9566-treated rats (C) as well as in the joints of Indomethacin-treated rats (D), compared with the controls (A). (Hematoxylin and eosin staining, ×14.1).