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. 2000 Dec;131(8):1513–1520. doi: 10.1038/sj.bjp.0703751

Figure 6.

Figure 6

Histological scores of bilateral tibiotalar joints of control, adjuvant control, BAY 12-9566-treated and Indomethacin-treated rats. In the right tibiotalar joint (the adjuvant-injected site), BAY 12-9566 significantly inhibited synovial necrosis and PMN infiltration, whereas Indomethacin suppressed osteoclast infiltration, bone remodelling, cartilage destruction synovial necrosis and capsular fibrosis. In the left tibiotalar joint (contralateral to the site of adjuvant injection), PMN infiltration was significantly lowered by both BAY 12-9566 and Indomethacin treatment.