Figure 5.

In vitro duration of antiaggregatory effects: (A) Rat platelet-rich plasma was preincubated with R-99224 (10 μg ml⁻¹) or PGE₁ (1 μM) for 1 min, and then ADP (10 μM)-induced platelet aggregation was measured before and after washing the platelets; (B) ADP (10 μM)-induced ex vivo aggregation of platelets from vehicle- or CS-747 (3 mg kg⁻¹, p.o.)-treated rats was measured before and after washing the platelets. Results are presented as the mean±s.e.mean (n=6). ^**P<0.01 vs each control.