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In vitro effect of R-99224 (0.1 – 1 μg ml−1) on ADP (10 μM)-induced cyclic AMP decrease in PGE1 (10 μM)-stimulated human platelets. ADP was added to the reaction mixture 3 min after PGE1 stimulation. Results are expressed as the mean±s.e.mean (n=6). **P<0.01 vs control.
