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Hyper-osmotic stress mimics the effects of NPPB to reveal relaxation of isometric arteries to K+. (a) In arteries where raising [K+]o from 5.88 to 10.58 mM did not produce relaxation, relaxation to K+ was induced in the presence of a hyper-osmotic solution (60 mM sucrose added). This effect was reversed by 30 μM Ba2+. (b) Mean data (n=6±s.e.mean). 10 μM ACh was still able to relax fully in the presence of Ba2+.
