Figure 3.

Changes in HWLs to mechanical (A) and thermal (B) stimulation and hindpaw volume (C) of the right hindpaw injected with carrageenan. The left hindpaw was injected with either saline, 0.3 mg of U-50,488H alone (U-50 contra) or equimolar concentrations of U-50,488H and naloxone methiodide (U-50+nalox). In systemic treatment, 0.3 mg of U-50,488H was injected subcutaneously (U-50 s.c.). Data are presented as percentage changes (%) and expressed in mean±s.e.mean (vertical axis). Horizontal axis indicates hours following injection. Significant differences are denoted as (*) contralateral U-50,488H versus systemic and (+) contralateral U-50,488H alone versus together with naloxone methiodide. Student's t-test. n=8 – 10. ^** and ++P<0.01; ^*** and +++P<0.001.