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The effect of clobetasol on codeine-induced histamine release, tissue histamine levels and dermal mast cell numbers. Areas of the volar forearm skin were treated for 21 days with either white soft paraffin (control) or 0.05% clobetasol propionate (steroid). (a) The peak histamine concentration recovered by microdialysis following intradermal injection of codeine (20 μl of 0.3 mM). (b) Tissue histamine levels and (c) mast cell numbers in biopsies taken at 21 days.
