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Heart rate (a) and mean arterial blood pressure (b) measured at various time points in the four groups of anaesthetized rabbits receiving vehicle (Control), mefloquine (MQ), halofantrine (HF) or halofantrine after 3 mg kg−1 mefloquine (HF+MQ). The arrows indicate the times at which bolus i.v. injections of 3 mg kg−1 mefloquine (M), or 1, 3, 10, and 30 mg kg−1 of mefloquine or halofantrine were given. Values are means with vertical bars indicating s.e.mean, n=6 per group.
