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Typical recordings demonstrating the effects of L-NOARG on preparations where MMCs did not propagate to the distal region of the colon. (a) Recording of a preparation lacking MMC activity in the distal region of the colon. (b) Addition of L-NOARG (100 μM; 20 min prior to the start of the recording shown) resulted in MMCs propagating to this region of the colon. Recordings were from the same preparation. Scale bars apply to both (a) and (b).
