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Effect of glibenclamide on [3H]-vincristine accumulation in GLC4/Sb30 and GLC4 cells. Cells were incubated with 20 nM [3H]-vincristine for 90 min in the presence or absence of 50 μM glibenclamide. Intracellular [3H]-vincristine accumulation was then determined by scintillation counting. The values are the mean±s.d.mean of at least three independent experiments in triplicate. *P<0.05 when compared to cells not treated by glibenclamide.
