Figure 1.

Effects of s-secoverine and darifenacin on the cumulative concentration-response curves of (+)-cis-dioxolane (a) on the dog urinary bladder smooth muscle and (b) on the brown-eyed dog ciliary muscle. Contractile effects were expressed as percentages of the maximum response of the control curve. The values shown are means±s.e.mean, n=2 – 7 animals. A single concentration of antagonist was applied to each tissue.