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. 2001 Mar;132(5):1111–1117. doi: 10.1038/sj.bjp.0703912

Figure 3.

Figure 3

Effects of acute morphine (10 mg kg−1) on the cyclic AMP levels in the mouse brain (A) and effects of rolipram (1 mg kg−1) on the decrease of cyclic AMP levels induced by morphine in the thalamus (B). (A) The control cyclic AMP levels in non-treated mice are 309.8±58.1 and 558.6±83.9 pmol g−1 tissue in the thalamus and cerebral cortex, respectively. n=6–7. *P<0.05 vs corresponding control. (B) The cyclic AMP levels in the thalamus of (Vehicle+Saline)-group are 322.8±48.3 pmol g−1 tissue. n=5–6. *P<0.05 vs (Vehicle+Saline)-group, #P<0.05 vs (Vehicle+Morphine)-group.