Figure 3.

Effect of max.d.4 on the ventral root depolarization evoked by noxious skin stimulation. Potentials were recorded extracellularly from the L3 ventral root of a spinal cord-saphenous nerve-skin preparation prepared from a 1-day-old rat. Capsaicin (0.1 μM) was applied to the skin during the period (30 s) indicated by the bars. (A) Sample records of capsaicin-induced depolarization. (a) Control response. (b) After pretreatment of max.d.4 (1 μM) to the medium superfusing the spinal cord for 15 min. (c) Forty-five minutes after the removal of max.d.4. (B) Each column and vertical bar represent mean±s.e.mean of the magnitude of capsaicin-induced depolarization (n=5) ^*P<0.05.