Figure 2.

In the absence of agonist, 5-HT_1A receptor antagonists can facilitate or depress evoked synaptic responses. (A) Normalized data showing the effects of NAN-190 or WAY-100635 on evoked synaptic responses. The antagonists could facilitate (black circles) or depress (grey circles) evoked synaptic responses. (B) Examples showing 5-HT_1A receptor antagonist-induced synaptic facilitation in younger (i) and older (ii) animals. In addition to synaptic facilitation spikes were recruited in the presence of WAY-100635 in (ii) and they are presented as lighter shaded events in the raw traces. These events were not included in the analysis of the average epsp amplitude increase at right. Note traces in B(i) are epscs, voltage clamp recording. B(iii) Example of synaptic depression produced by NAN-190. Percentage change in peak synaptic response in the presence of the ligands were 27%↑, 29%↑ and 37%↓, respectively.