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. 2001 Apr;132(8):1789–1798. doi: 10.1038/sj.bjp.0703983

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Copyright 2001, Nature Publishing Group

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Unidentified receptors mediate part of the depressant actions of 5-HT. (A) 5-HT-evoked epsp depression is partly reversed in the presence of the 5-HT_1A receptor antagonist NAN-190. (B) NAN-190 has no effect on 5-HT-evoked depression while washout of 5-HT leads to a near complete recovery of synaptic amplitude. (C) WAY-100635, clozapine, 8-OH-DPAT, or CGS has no effect on the evoked synaptic responses. However, 5-HT produces potent depression of the epsp, which is unchanged by NAN-190, suggesting that 5-HT receptors other than 5-HT_1A, 5-HT_1B or 5-HT₇ are mediating the depressant action of 5-HT. In C only, the individual traces are presented superimposed in grey, while the average response is presented overlaid as a thick-black trace.