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5-HT7 receptor antagonist partly reverses 5-HT-evoked facilitation, but not 5-HT-evoked depression of epsps. (A) The 5-HT-induced facilitation (35%) of epsp amplitude in a neuron obtained from an older animal is blocked by clozapine, allowing 5-HT to produce synaptic depression, presumably by actions on other receptor subtypes. (B) Clozapine does not remove the synaptic depression evoked by 5-HT.
