Figure 2.

Levels of dopaminergic nerve terminals, measured as density of specific [³H]-mazindol binding (nCi mm⁻²) within the striatum of wild-type and α4 nAChR subunit knockout mice treated with methamphetamine (5 mg kg⁻¹; three injections i.p.; METH) and nicotine (1 mg kg⁻¹; s.c.) plus methamphetamine (nicotine+METH). Each column represents the mean and s.e.mean of averaged triplicates or quadruplicates of the density of specific [³H]-mazindol binding measured in striata taken from 3 – 8 mice. Differences in dopaminergic nerve terminal survival were assessed by one-way ANOVA with a Dunnett's post-hoc test for multiple comparisons with a control, in wild-type and knockout mice, respectively, where P<0.05 was considered statistically significant. ^* (P<0.05).