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. 2001 Apr;132(8):1817–1826. doi: 10.1038/sj.bjp.0703992

Figure 2.

Figure 2

[125I]-ICYP competition curves in human left ventricular myocardium from a nonfailing heart. (A, C, E) ICYP-nebivolol competition in the absence and presence of 100 μmol l−1 of Gpp(NH)p. (B, D, F) ICYP-bisoprolol competition in the absence and presence of Gpp(NH)p. (A, B) competition experiments in a mixed β1- and β2-adrenoceptor population. (C, D) Experiments in the presence of ICI 118.551 (50 nmol l−1), determining the affinity of the respective β-blocker to β1-adrenoceptors. (E, F) Experiments in the presence of CGP 207.12A (300 nmol l−1), determining the affinity of the respective β-blocker to β2-adrenoceptors. (G, H) All experiments in the presence of Gpp(NH)p, in the presence of ICI 118.551 or CGP 207.12A, respectively, indicating β1-selectivity of the β-blockers.