Figure 3.

Gastrin-evoked mobilization of histamine in fasted rats (A), freely fed rats (B) and rats treated with omeprazole daily for 1 week (C). Omeprazole was given by the oral route. Gastrin-17 was given by continuous intravenous infusion in doses as indicated. The pre-gastrin level of histamine in the microdialysate of freely fed rats (34.3 nmol l⁻¹±1.5) was 1.5 times higher than in fasted animals (22.7 nmol l⁻¹±0.1); in omeprazole-treated rats the pre-gastrin histamine level (145 nmol l⁻¹±6.2) was seven times higher than in the fasted rats. Means±s.e.mean (36 – 48). Gastrin dose-response curves (D) were constructed (using the GraphPad PRISM program) for the three groups of rats based on 4-h integrated increments in histamine.