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Concentration-dependent inhibition of MCh (4.2×10−7 M)-induced ICl(Ca) in oocytes expressing m3 muscarinic receptors by (A) intracellularly injected QX314 (IC50 445±226 μM), (B) extracellularly administered benzocaine (IC50 258±182 μM) and (C) intracellularly applied lidocaine (IC50 341±33 μM).
