Figure 5.
Proliferative response of splenocytes from nitroso sulphamethoxazole-treated rats (1 mg kg−1) cultured with sulphamethoxazole, sulphamethoxazole hydroxylamine or nitroso sulphamethoxazole for 72 h. Proliferation was determined by incorporation of [3H]-thymidine over an additional 8 h. The cpm in the control cultures (DMSO alone) did not exceed 600. Results are presented as mean±s.d. from four rats, incubations carried out in triplicate. Statistical analysis compares drug-treated splenocytes with cells containing DMSO (*P<0.05).