Figure 6.
Dose-dependent proliferative response of splenocytes from nitroso sulphamethoxazole-treated rats (0.01 – 10 mg kg−1) cultured with nitroso sulphamethoxazole for 72 h. Proliferation was determined by incorporation of [3H]-thymidine over an additional 8 h. The c.p.m. in the control cultures (DMSO alone) did not exceed 600. Results are presented as mean±s.d. from four rats, incubations carried out in triplicate. Statistical analysis compares drug-treated splenocytes with cells containing DMSO (*P<0.05).