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Influence of AS-8112 or various compounds upon the change in rectal temperature by R(+)-7-H-DPAT (1 mg kg−1 s.c., 30 min). Saline or test compound was administered s.c. 30 min before treatment with R(+)-7-OH-DPAT (1 mg kg−1 s.c.). Statistically significant difference from the saline treated group is indicated by *P<0.05, **P<0.01, Dunnett's multiple comparison test. Data are the means, n=5 – 14. s.e.'s did not exceed ±0.29°C of mean values.
