Effect of vehicle, SB215,505 (3 mg kg−1), MDL100,907 (0.5 mg kg−1) against the hyperactivity (A) and hyperthermia (B) produced the combination of dexfenfluramine (10 mg kg−1) and SB242,084 (0.5 mg kg−1). *P<0.05 vs respective vehicle group. #P<0.05 vs dexfenfluramine/SB242,084/veh group (Newman-Keuls test).