Concentration-dependent effects of Ca2+ channel antagonists on serotonin release. The concentration-dependent effects of Ca2+ channel antagonists, on basal, Ca2+- and K+-evoked hippocampal serotonin releases are represented in a, b and c, respectively. The ordinates indicate the mean±s.d. (n=6) of serotonin release level (fmol sample−1), and abscissas show the concentration of Ca2+ channel antagonists (μM). The mean values of serotonin release obtained between perfusion without (control) and with Ca2+ channel antagonists were compared by one-way ANOVA with Tukey's multiple comparison (*: P<0.05; **: P<0.01).