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Role of E-selectin in KC-induced neutrophil accumulation. Mice were treated with an i.v. injection of control IgG (non-blocking P- and E-selectin mAbs), anti-P-selectin mAb alone or anti-P- and -E-selectin mAbs in combination. KC (0.1 μg) was administered into the pleural cavity and neutrophil accumulation measured after (a) 2 h or (b) 4 h. Values represent mean±s.e.mean of 4–6 mice. *P<0.05 compared with KC by one-way ANOVA followed by Student-Newmann-Keuls post-test.
