Figure 1.

Representative traces showing simultaneous recording of changes in smooth muscle tension (mN) and membrane potential (mV) to bolus doses of authentic NO (1–150 μmoles) in an endothelium-denuded artery segments pre-stimulated with phenylephrine (1 μM) in the absence (a) and presence (b) of ODQ (10 μM). In the presence of ODQ, the concentration of phenylephrine was reduced to 0.6 μM to ensure that a comparable level of pre-contraction and depolarization was achieved. Vertical lines denote loss of electrode impalement.