Figure 5.

Mean concentration-response curves for SIN-1-evoked relaxation in (a) endothelium intact arteries where relaxation was abolished by either 4-AP (0.5 mM) or IbTX (50 nM) alone, an action which was additive. (b) In denuded arteries, 4-AP was without effect unless it was combined with ODQ or ODQ and IbTX. All points are the means of six observations with the s.e.mean shown by the vertical lines.