Figure 2.

Effect of the study drugs and their combinations on weight gain during the observation period. Data (mean±standard deviation, n=12) shows the per cent change at the beginning of each study day in comparison with the weight at day 1 prior to dosing (=100%). The study drugs were administered by oral gavage for 6 days. The rats (2-weeks old, mean weight 28±4 g) received the following doses: control, 13 ml vehicle (10% ethanol in milk); Cs, 10 mg kg⁻¹ d⁻¹ cyclosporine; SRL, 3 mg kg⁻¹ d⁻¹ sirolimus; RAD, 3 mg kg⁻¹ d⁻¹ RAD; Cs+SRL, 10 mg kg⁻¹ d⁻¹ cyclosporine+3 mg kg⁻¹ d⁻¹ sirolimus; Cs+RAD, 10 mg kg⁻¹ d⁻¹ cyclosporine+3 mg kg⁻¹ d⁻¹ RAD. (A) Comparison of groups Cs, SRL and Cs+SRL; (B) comparison of groups Cs, RAD and Cs+RAD. The results of the control group and Cs are shown in both (A) and (B) to facilitate comparison.