Figure 3.

Representative ¹³C-MRS spectra of brain PCA extracts from rats in the control (A) and mono-treatment groups Cs (B), SRL (C), and RAD (D). Rats were treated with the following doses by oral gavage for 6 days: (A) control, 13 ml vehicle (10% ethanol in milk, total n=7), (B) Cs, 10 mg kg⁻¹ d⁻¹ cyclosporine (n=5), (C) SRL, 3 mg kg⁻¹ d⁻¹ sirolimus (n=5) and (D) RAD, 3 mg kg⁻¹ d⁻¹ RAD (n=5). Abbreviations: Asp, aspartate; Cr, creatine; Cs, cyclosporine; GABA, γ-aminobutyric acid; Glc, glucose; Gln, glutamine; Glu, glutamate; Ins, myo-inositol; Lac, lactate; NAA, N-acetyl aspartate; OAA, oxaloacetate; SRL, sirolimus; Tau, taurine.