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Effects of (a) PNU-142633 and (b) LY334370 on neurogenic dural vasodilation in anaesthetized guinea-pigs. Vasodilation was evoked by local electrical stimulation (approx. 275 μA, 1 ms, 5 Hz for 10 s) of the dura. Each column represents the mean percentage increase in diameter±s.e.mean of (a) 8-11 and (b) 7-11 guinea-pigs. *Significantly different from control (P<0.05).
