Figure 4.

Effect of nepadutant (0.1 μmol kg⁻¹, i.v.), atropine (1.4 μmol kg⁻¹ h⁻¹), or hexamethonium (13.5 μmol kg⁻¹ h⁻¹) on intracolonic pressure induced by the filling of the colonic balloon with 0.5 ml and luminal application of 0.5 ml of acetic acid 7.5% v v⁻¹ in saline: (a) MAC, maximal amplitude of contractions; (b) AUC, area under the curve; (c) Minimal Pressure. Results are expressed as difference (Δ) in respect to baseline values. Fisher LSD test: *P<0.05 and **P<0.01 vs time-matched controls. Each point and bar represents the mean±s.e.mean of 12 experiments.