The effect of atropine, hexamethonium, or nepadutant on [βAla8]NKA(4-10) (10 nmol kg−1, i.v.)-induced colonic contractions (MAC) in: vehicle-pretreated (a), L-NAME-pretreated (b), or hexamethonium-pretreated preparations (c). Each point and bar represents the mean±s.e.mean of 8–10 experiments. Fisher LSD test: *P<0.05 and **P<0.01 vs Vehicle.