Figure 1.

Dose-dependent effects of cyclosporin A on morphology and survival of hippocampal neuronal/glial cultures. Hippocampal dentate gyrus cultures were prepared as described in Materials and methods. Cells were exposed to various doses of cyclosporin A and monitored for 24–72 h by phase-contrast microscopy at 20×. The panels show untreated cells (A); cultures treated with CsA: 8, 40, 200 μM (B, C, and D respectively).